Investigators: Dr Sungwon Chang (CI)

The aim of this program of research is to describe patterns and to identify risk characteristics associated with hospital admission and mortality in older women with CHF. By developing risk prediction models for older women with CHF, the research program helps understand the factors antecedent to hospitalisation and mortality, essential to developing targeted and tailored strategies to improve health service delivery. In addition, this project will describe patterns and trends in evidence-based CHF therapy utilisation amongst women over time.

Investigators: Ms Joanne Atkins, Prof Nick Glozier, Prof Ian Hickie (CI), A/Prof Sharon Naismith, Dr Matthew Paradise.

The aims of this project were to determine which single or combined cardiovascular risk factors predict psychological distress/depression, and to determine the major associations of physical health and psychological distress with measures of disability among participants in the 45 and Up Study of working age (<65 years). It also hoped to provide understanding of key factors predicting disability and quality of life in the NSW population.

Outcomes resulting from this research:

Paradise MB, Glozier NS, Naismith SL, Davenport TA, Hickie, IB. Subjective memory complaints, vascular risk factors and psychological distress in the middle-aged: a cross-sectional study. BMC Psychiatry 2011 July 1;11:108. doi:10.1186/1471-244X-11-108

Paradise MB, Naismith SL, Davenport TA, Hickie IB, Glozier NS. The impact of gender on early ill-health retirement in people with heart disease and depression. Aust N Z J Psychiatry 2012;46(3):249–56. doi: 10.1177/0004867411427807

Investigators: Prof Emily Banks, Prof Adrian Bauman (CI), Prof John Chalmers.

The aims of this study were to analyse cardiovascular disease and diabetes by socio-demographic factors in the baseline 45 and Up dataset; to examine the sub types of cardiovascular disease, diabetes or renal disease that are available in the 45 and Up data set; and to examine the risk for people who have already with reported heart disease, hypertension, diabetes, stroke, and renal disease. The risk factor profile sought were those risk factors that could be identified through the baseline dataset, including profiling by physical activity level, obesity, smoking status and some nutritional patterning.

Outcomes resulting from this research:

The project produced an important report on baseline prevalence rates of cardiovascular and related risk factors. The investigators of this project also provided valuable feedback to the 45 and Up Study, relating to methodology, which resulted in beneficial updates to the 45 and Up Study’s baseline data.

Investigators: Dr Sally Inglis (CI)

The principal aim of this research is to examine the epidemiology, outcomes and management of peripheral arterial disease (PAD) in the 45 and Up Study.

Investigators: Prof John Attia, Prof Emily Banks, Prof Adrian Bauman, Prof Ian Caterson, Prof John Chalmers, Ms Tien Chey, Prof Don Chisholm, Prof Vicki Flood, A/Prof Tim Gill, Prof Leonard Kritharidis, Ms Isabel Latz, Prof Christopher Levi, Prof Peter MacDonald, Dr Christopher Magee, Ms Suan Peng Ng, Dr Alex Peng, Dr Hidde van der Ploeg, Prof Carol Pollock, Dr Katherine Samaras, Prof Mark Woodward.

Cardiovascular disease remains the highest cause of death for adult Australians. Through linking the data obtained through the 45 and Up Study with other data sources, this study aims to investigate risk factors for cardiovascular disease. The study will investigate a number of established and emerging risk factors for cardiovascular disease including physical activity/inactivity, erectile dysfunction, short sleep duration, diabetes, nutrition and obesity. By examining the relationship between cardiovascular disease and these proposed risk factors the study hopes to provide much needed information about the disease in the Australian context.

Investigators: Dr Christine Chiu, Prof Annemarie Hennessy, Dr Joanne Lind, Ms Samantha Lupton, Dr Angela Makris, Dr Aiden O’Loughlin, Ms Charlene Thornton, Ms Jane Tooher.

This study aims to investigate possible risk factors for cardiovascular disease. In particular the study will investigate risk factors for which there is limited information on their association to cardiovascular disease, including age, gender, exogenous hormone use, high blood pressure during pregnancy and breastfeeding.

Investigators:  Dr Alys Havard, Ms Caroline Joyce (CI & PhD Student) with supervisor Dr Kathryn Nicholson Perry, Prof Ian Wilson.

Anxiety and depression are common in people with coronary heart disease, predicting worse outcomes. In the general population depression and anxiety increase the risk of developing coronary heart disease. By using the baseline data from the 45 and Up Study, this project will examine the relationship between a history of anxiety and/or depression and the onset of coronary heart disease.  It will also compare  psychological distress following a cardiac event between those with and without a history of either anxiety or depression.

Investigators: Melina Gattellari (CI), Bin Jalaludin, John Worthington.

This study aims to identify the prevalence and management of stroke risk factors, such as diabetes, hypertension, congestive heart failure, atrial fibrillation, age, smoking and diet. It will also examine the risk factors for the development of Parkinson’s disease, heart disease and stroke, how these risk factors are managed and the impact of these conditions on quality of life and daily living activities. Further, the project aims to determine the outcomes for patients with stroke, heart disease and Parkinson’s disease, such as self-rated quality of life and health status, prevalence of depression and anxiety, and the prevalence and management of risk factors where relevant. Variability in outcomes according to socioeconomic status, age, gender and risk factors will also be ascertained.