Investigators: Thomas Astell-Burt (CI), Andrew Page, Dafna Merom, Emma George, Freya Macmillan, Xiaoqi Feng, Amelia Cook, Andrew Bennie, Bonnie Pang, Fran Moran, Genevieve Dwyer, Gregory Kolt, Hosmaldien Kamel, Sabrina Naz, Xidan Chen, Aymen El Masri This project will investigate specific pathways (social, biological, behavioural, psychological, environmental) to identify trajectories, transitions and tipping points in physical and mental health as people age, to advise when, where and for whom preventive health interventions can be optimally targeted.