Investigators: Dr Anne Cust, Prof Scott Menzies, Prof Graham Mann, Dr Rachael Morton, Ms Caroline Watts (CI). Cutaneous melanoma is the third most common cancer in NSW. Family history or personal history of melanoma, many moles or atypical moles, and fair skin will place an individual at higher risk of melanoma than the general population. Early detection is a primary factor in survival and the rationale for targeting individuals at high risk of melanoma. The introduction of a specialised clinic at Royal Prince Alfred Hospital in 2006 was a major initiative to improve the care of individuals at high risk of melanoma in NSW. In 2012, the high-risk clinic model will be expanded to three more centres in NSW. The study is a modelled economic evaluation utilising data of health care costs and outcomes associated with a diagnosis of melanoma, managed in either a high-risk clinic or in the community. The objective is to determine whether it is cost effective to manage individuals considered at high risk of melanoma in a specialised setting (a high-risk clinic) compared with standard care, from a societal and Australian health system perspective.