Investigators: Alys Havard (CI), Louisa Jorm, Danielle Tran, Sanja Lujic

Pharmaceutical products, including Zyban, Champix and nicotine replacement therapy, are the most effective strategies available to help people quit smoking. This project will measure the safety of these medications by linking pharmaceutical prescription records to records of other health service use.

Investigators: Jane Estoesta (CI), Wendy Cheng, Jodie Duggan, Kevin McGeechan, Deborah Bateson, Mary Stewart, Kristine Concepcion, Jessica Botfield

Using the 45 and Up Study, MBS and PBS data we will aim to:

  • Assess the demographic, socioeconomic characteristics and health issues of men and women aged 45 to 64 years
  • Review the MBS and PBS items being utilised by this age group
  • Determine whether people of this age group seek for medical care.

Investigators: Guy Marks (CI), Helen Reddel, Leanne Poulos, Neil Hime, Maria Ampon, Arianne Schlumpp

The aims of the Respiratory Outcomes Linkage Study – data linkage using the 45 and Up Study (ROLS-45) are to ascertain the impacts that comorbid obstructive airways disease and cardiovascular disease have on health outcomes in 45 and Up Study participants, and the impact that the use of specific respiratory medications has on health outcomes in participants with obstructive airways disease.

Investigators: Mark Bartlett (CI), Efty Stavrou, Liz Hay, Glen Pang

This project aims to describe the health service use (both community and acute) in the older person with complex health needs, and has the following two objectives:

  1. To describe the nature of service use (occasion of service by service type), both community and acute care, in the older person with complex health needs (that is, people aged 65 years and older with a health condition consistent with the ‘geriatric syndrome’)
  2. To compare service use in the older person with complex health needs to an equivalent group of people without ‘geriatric syndrome’.

Investigators: Henry Brodaty (CI), Megan Heffernen, Perminder Sachdev, John McNeil, Anthony Maeder, Nicola Lautenschlager, Louisa Jorm, Maria Fiatarone Singh, Kaarin Anstey, Gavin Andrews

Maintain Your Brain (MYB) is a randomised controlled trial of multiple online interventions designed to target modifiable risk factors for Alzheimer’s disease and deme. Risk factors to be addressed are physical inactivity, cognitive inactivity, depression, overweight and obesity, and poor diet. Four intervention modules (physical activity and nutrition, cognitive training and depression) will be customised to individual risk profiles. Each module will be initially delivered using MYB eHealth platform over three months. In the active intervention phase participants complete all four modules is 12 months. Booster sessions and monitoring will continue for four years. Follow-up assessments measuring these risk factors and cognition will be completed annually for four years. The comparison control group will receive basic psychoeducation online about dementia risk factors and otherwise receive usual care and undertake the same set of assessments.

Investigators: Dr Sungwon Chang (CI)

The aim of this program of research is to describe patterns and to identify risk characteristics associated with hospital admission and mortality in older women with CHF. By developing risk prediction models for older women with CHF, the research program helps understand the factors antecedent to hospitalisation and mortality, essential to developing targeted and tailored strategies to improve health service delivery. In addition, this project will describe patterns and trends in evidence-based CHF therapy utilisation amongst women over time.

Investigators: Elizabeth Comino (CI), Mark Harris, Elizabeth Harris, Julie McDonald, Tish Bruce, Amanda Jones, Debra Donnelly, Judie Page

The objectives are:

  1. To establish a 45 and Up Primary and Community Health Cohort by linking the 45 and Up Study to administrative datasets held by local, state and commonwealth data collections
  2. To examine the influence of participant and system factors on integration of health services and its impact on health outcomes and health service use over time
  3. To determine the health outcomes and service needs of older residents
  4. To identify the factors associated with ‘healthy’ ageing and older residents’ trajectory towards higher care need
  5. To identify the care pathways for a cohort of older people
  6. To identify predictors of health service use and develop interventions to address them
  7. To monitor the impact of integration programs on health service use and patterns of hospitalisation
  8. To evaluate interventions and policies to improve health outcomes of older residents
  9. To enhance the effective implementation of successful strategies based on study findings by working with health service staff, management and policy makers.

Investigators: Peter Lewis (CI), Tina Navin-Cristina, Richard Broome, Louisa Jorm, Alex Stephens, Mark Bartlett, Joanna Wang

The purpose of this project is to develop predictive models of impending emergency hospital admission, emergency department attendance, residential aged care admission, significant change in health state or death. That is, to identify indicators of an individual’s declining health, with the view to pre-emptive intervention. Validated predictive models will also support evaluation of the integrated care models implemented by NSW LHDs.

Investigators: Kim Sutherland (CI), Douglas Lincoln, Julia Chessman, Jean-Frédéric Lévesque, Jason Boyd

The objective is the development of outcome and process indicators with specific adjustments and allowances for patient factors and access to primary care for a more complete measurement of the performance of the NSW public healthcare system.

The general aims for addressing specific questions of healthcare system performance are:

  • Identify a valid and appropriate patient cohort from the 45 and Up Study population
  • Develop an indicator, or suite of indicators making adjustments for patient-reported health and social factors; contacts with primary care sector; and historical and current prescription drug use
  • Develop and release a public report, with companion technical publications, that provides an accurate, fair and comprehensive picture of performance of the NSW public healthcare system in the specified area.

Investigators: Anna Cohen (CI), Mireille Campbell, Bill Sun, George Zu, Christa Marjioribanks, Catherine Miles, Timothy Darmanin

The objectives of this project are to estimate the “true” breast screening participation rate across public and private screening avenues in NSW, and to understand and compare the demographic profiles, screening patterns, interval cancer prevalence, and cancer mortality rates of women screened through BreastScreen NSW and outside BreastScreen NSW. To meet these objectives, data linkage to the 45 and Up Study will enable these objectives to be measured. The results of the project will be used to inform BreastScreen NSW strategy aimed at increasing the breast screening participation rate of women in NSW.